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  1. Although the exact mechanism involved in migraine pathogenesis remained uncertain, and different researches have been developed to address the role of neuroinflammation and immune dysfunction. Therefore, consi...

    Authors: Zeinab Ghorbani, Pegah Rafiee, Samaneh Haghighi, Soodeh Razeghi Jahromi, Mahmoud Djalali, Hedieh Moradi-Tabriz, Maryam Mahmoudi and Mansoureh Togha
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:9
    Content type: Research article Published on:

  2. Pharmaceutical care of capecitabine-related hand–foot syndrome (HFS) is extremely important to avoid the progression of the syndrome. Protocol-based pharmacotherapy management (PBPM) of HFS by community pharma...

    Authors: Nobuhiko Nakamura, Hiroki Shiraiwa, Yasuhiro Haruna, Tomoki Ichijima, Tomoko Takeda, Koji Hasegawa, Masaaki Kusumoto and Yoshitaka Yano
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:8
    Content type: Research article Published on:

  3. Combinations of antidepressant duloxetine (at doses of 40–60 mg/day) and other antipsychotics are frequently used in clinical treatment; however, several fatal and nonfatal cases of duloxetine overdose have be...

    Authors: Koichiro Adachi, Satoru Beppu, Kei Nishiyama, Makiko Shimizu and Hiroshi Yamazaki
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:6
    Content type: Case report Published on:

  4. Phenobarbital (PB) is commonly used as elixir and powder formulations in pediatric care. Its dose adjustment is performed based on individual drug concentration monitoring. Few studies have comprehensively ana...

    Authors: Chihiro Shiraishi, Hiroko Matsuda, Toru Ogura and Takuya Iwamoto
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:7
    Content type: Research article Published on:

  5. The standard anticoagulation therapy for patients implanted with left ventricular assist devices (LVADs) includes warfarin therapy. We developed a cloud-based home medical management information-sharing system...

    Authors: Yoshiki Katada, Atsushi Yonezawa, Momoe Utsumi, Noriaki Kitada, Yu-ki Sato, Katsuyuki Matsumura, Asami Sukeishi, Shunsaku Nakagawa, Satoshi Imai, Takayuki Nakagawa, Kenji Minakata, Hideo Kanemitsu, Kenji Minatoya, Shinichi Nomoto and Kazuo Matsubara
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:5
    Content type: Case report Published on:

  6. The most common adverse event (AE) associated with opioid analgesics is opioid-induced constipation (OIC). Naldemedine (NAL) is widely used for the treatment of OIC. However, diarrhea has been reported as the ...

    Authors: Akiharu Okamoto, Kenji Ikemura, Eri Mizutani, Takuya Iwamoto and Masahiro Okuda
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:3
    Content type: Research article Published on:

  7. Fibrocystic changes are a common benign condition in women aged 20–50. The medical intervention aims to stop fibrocystic disease progress and relieve the breast’s pain and tenderness. In the long-term, reversi...

    Authors: Gholamali Godazandeh, Shahram Ala, Tahereh Madani Motlaq, Adeleh Sahebnasagh and Aliyeh Bazi
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:4
    Content type: Research article Published on:

  8. Elastomeric pumps (EPs) are devices that allow quantitative and continuous drug administration without the need for electronic control, and they are used by being filled with anticancer agents. Although the pa...

    Authors: Tomoya Abe, Kazumasa Matsuzaka, Toshiaki Nakayama, Masanobu Otsuka, Atsunobu Sagara, Fumiaki Sato and Tetsuro Yumoto
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:1
    Content type: Research article Published on:

  9. The effects of general anesthesia with deep sedation and conscious sedation have been compared for sedation management in the perioperative period for radiofrequency catheter ablation of the heart to treat atr...

    Authors: Teruhisa Kinoshita, Mitsunori Harada, Norio Takimoto, Daichi Shibata, Takashi Sakakibara and Mamoru Adachi
    Citation: Journal of Pharmaceutical Health Care and Sciences 2021 7:2
    Content type: Research article Published on:

  10. Generic drugs are heavily promoted in Japan. The aim of this retrospective single-center study was to clarify whether the frequency and reason that patients request a switch from a generic drug to the original...

    Authors: Yuhei Hamada, Masashi Uchida, Sayaka Arai, Kaori Yamazaki, Mariko Takeda, Kenichi Arai, Takako Nakamura, Takaaki Suzuki and Itsuko Ishii
    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:27
    Content type: Research article Published on:

  11. Although recombinant human soluble thrombomodulin (rTM) has been widely used to treat disseminated intravascular coagulation (DIC) in Japan, there is no consensus regarding rTM efficacy. Therefore, if the fact...

    Authors: Yuki Asai, Takanori Yamamoto, Daisuke Kito, Kazuya Ichikawa and Yasuharu Abe
    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:26
    Content type: Short report Published on:

  12. Xanthan gum-based food thickeners (XG-FTs) are often ingested by patients with dysphagia to prevent aspiration during drug treatment. Reportedly, XG-FTs affect tablet disintegration, drug dissolution rates, an...

    Authors: Nobuyuki Takahashi, Yoshiaki Fujita, Nanako Takahashi, Akihiro Nakamura and Tsutomu Harada
    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:25
    Content type: Research article Published on:

  13. While the world’s population is growing older, healthy life expectancy is not increasing. The Japanese Orthopedic Association proposed the concept of ‘locomotive syndrome,’ manifested as a decline in mobility ...

    Authors: Chigusa Kikuchi, Kyoko Yamaguchi, Masayo Kojima, Haruyuki Asai, Rika Nakao, Yoshifusa Otake, Junya Nagata, Shinpei Matsunami, Asako Horiba and Tadashi Suzuki
    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:24
    Content type: Research article Published on:

  14. Permeability of antineoplastic agents through medical gloves is an important factor that must be considered for the appropriate selection of gloves. However, predicting the permeability of antineoplastic agent...

    Authors: Toyohito Oriyama, Takehito Yamamoto, Katsuhiko Nara, Yohei Kawano, Katsuyoshi Nakajima, Hiroshi Suzuki and Takao Aoyama
    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:23
    Content type: Research article Published on:

  15. We collaborated with the regional pharmaceutical associations near Nagoya Memorial Hospital and created a communication sheet for pharmaceutical cooperation between the hospital and health insurance pharmacies.

    Authors: Megumi Kabeya, Satoshi Hibi, Shu Yuasa, Satoshi Kayukawa and Kenji Ina
    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:22
    Content type: Research article Published on:

  16. Baloxavir marboxil (baloxavir) is a new anti-influenza virus agent that is comparable to oseltamivir phosphate (oseltamivir). Since the efficacy of baloxavir in preventing household transmission of influenza i...

    Authors: Takumi Umemura, Yoshikazu Mutoh, Takato Kawamura, Masayuki Saito, Takahito Mizuno, Aiko Ota, Koji Kozaki, Tetsuya Yamada, Yoshiaki Ikeda and Toshihiko Ichihara
    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:21
    Content type: Research article Published on:

  17. The anticoagulant edoxaban is used clinically at doses of 30–60 mg/day; however, we experienced a patient who had taken an overdose of edoxaban of 750 mg. We investigated the pharmacokinetics of edoxaban in th...

    Authors: Koichiro Adachi, Jumpei Tuchiya, Satoru Beppu, Kei Nishiyama, Makiko Shimizu and Hiroshi Yamazaki
    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:20
    Content type: Case report Published on:

  18. Bevacizumab (BEV) leads to proteinuria and renal damage. It is not clear whether the administration of immunosuppressive drugs after renal transplantation affects the safety of BEV administration. We report a ...

    Authors: Ren Onodera, Satoru Nihei, Toshimoto Kimura, Takashi Tomita and Kenzo Kudo
    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:19
    Content type: Case report Published on:

  19. Ward pharmacists are required for the active implementation of therapeutic drug monitoring (TDM). This epidemiological study verified whether Japanese ward pharmacists contribute to improving the TDM implement...

    Authors: Shungo Imai, Kenji Momo, Hitoshi Kashiwagi, Takayuki Miyai, Mitsuru Sugawara and Yoh Takekuma
    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:18
    Content type: Research article Published on:

  20. Many patients with critical lower limb ischemia are not eligible for revascularization procedures. Still, given the emerging role of both platelet and coagulation activation in the formation of arterial thromb...

    Authors: Antonio Trani, Pietro Benedetto, Ferdinando Di Leo, Angela Baiano, Andrea Esposito, Danilo Menna, Arianna Allegretti, Pierluigi Antonino Cappiello and Domenico Dell’Edera
    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:17
    Content type: Case report Published on:

  21. Valganciclovir (VGC) is essential for preventing cytomegalovirus infections after transplants in adult and pediatric patients. In pediatric patients, VGC tablets have to be pulverized so that they can be deliv...

    Authors: Yasuyuki Masaoka, Yoichi Kawasaki, Ryo Kikuoka, Atsushi Ogawa, Satoru Esumi, Yudai Wada, Soichiro Ushio, Yoshihisa Kitamura and Toshiaki Sendo
    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:16
    Content type: Research article Published on:

  22. Instillation of sterile graded talc in the pleural space is performed to prevent reaccumulation of malignant pleural effusion after drainage. Talc is thought to encourage pleural adhesions as part of the repai...

    Authors: Soichiro Ishii, Hiroshi Sakurashita, Emiko Mashida, Yasuyuki Saeki and Hiroaki Matsuo
    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:15
    Content type: Case report Published on:

  23. The need for a large volume of serum sample significantly reduces the feasibility of neonatal pharmacokinetic studies in daily practice, which must often rely on scavenged or opportunistic sampling. This probl...

    Authors: Jumpei Saito, Ayano Tanzawa, Yuka Kojo, Hidehiko Maruyama, Tetsuya Isayama, Kensuke Shoji, Yushi Ito and Akimasa Yamatani
    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:14
    Content type: Research article Published on:

  24. Patients with diabetes are at higher risk of developing polypharmacy because of the high frequency of comorbidities. There have been several reports on the hypoglycemic risk of the combination of hypoglycemic ...

    Authors: Tomoyuki Saito, Hirotoshi Ohmura, Shuko Nojiri and Hiroyuki Daida
    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:13
    Content type: Research article Published on:

  25. Oral mucositis frequently occurs in cancer patients treated with chemotherapy and chemoradiotherapy (CRT). This study examined the safety and efficacy of ibuprofen gargle in healthy volunteers and patients wit...

    Authors: Takeshi Ioroi, Naomi Kiyota, Yoshinori Imamura, Masaaki Tanda, Shiori Aoki, Mamoru Okuno, Kazuhiro Yamamoto, Ryohei Sasaki, Ken-ichi Nibu, Hironobu Minami, Midori Hirai and Ikuko Yano
    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:12
    Content type: Research article Published on:

  26. Itraconazole (ITZ), a triazole antifungal agent, is metabolized to hydroxy-ITZ (OH-ITZ), keto-ITZ (KT-ITZ), and N-desalkyl ITZ (ND-ITZ) by cytochrome P450 3A4. The pharmacokinetics of ND-ITZ remain largely unknow...

    Authors: Yumi Imoto, Yasuaki Mino, Takafumi Naito, Takaaki Ono and Junichi Kawakami
    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:11
    Content type: Research article Published on:

  27. Pain treatment post orthopaedic care in the elderly is complicated and requires careful follow-up. Current guidelines state all patients prescribed opioids should have a plan for gradual reduction, with the tr...

    Authors: Gabriella Caleres, Patrik Midlöv, Åsa Bondesson and Sara Modig
    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:10
    Content type: Research article Published on:

  28. Effective treatment for human immunodeficiency virus (HIV) infection requires close cooperation among healthcare professionals. This is because maintaining continuity with treatment regimens is important in an...

    Authors: Kimihiko Urano, Miki Ishibashi, Takeshi Matsumoto, Kohshi Ohishi, Yuichi Muraki, Takuya Iwamoto, Junichi Kunimasa and Masahiro Okuda
    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:9
    Content type: Research article Published on:

  29. Autism spectrum disorder (ASD) is a neurodevelopmental disorder, mainly characterized by impairment of social communication and restricted interests. ASD is frequently accompanied by attention deficit hyperact...

    Authors: Taisuke Kitaoka, Masahito Morimoto, Toshiaki Hashimoto, Yoshimi Tsuda, Tadanori Nakatsu and Shojiro Kyotani
    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:8
    Content type: Research article Published on:

  30. Four-factor prothrombin complex concentrate (4F-PCC) must be administered as soon as possible, and in our emergency intensive care unit (EICU), pharmacists are available on weekdays for consultation on expedit...

    Authors: Shoichi Imanaka, Tatsuro Kuwabara, Hiroto Ikeda, Yasufumi Miyake, Hiromi Enomoto, Tetsuya Sakamoto and Nobuhiro Yasuno
    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:7
    Content type: Research article Published on:

  31. Interferon and ribavirin have been used as therapeutic agents for chronic hepatitis C infection or C-compensated cirrhosis in the conventional treatment. Hepatitis C virus (HCV) -specific direct-acting antivir...

    Authors: Sachiko Omotani, Toshihiko Ishizaka, Miki Inoue, Koji Nishida, Yukako Yasui, Yasutoshi Hatsuda, Junji Mukai and Michiaki Myotoku
    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:6
    Content type: Case report Published on:

  32. Repaglinide is widely prescribed to reduce postprandial hyperglycemia and elevated glycated hemoglobin (HbA1c) levels associated with type 2 diabetes, and clopidogrel is a thienopyridine antiplatelet agent and...

    Authors: Yuuki Akagi, Akiko Iketaki, Haruna Kimura, Yuki Matsudaira, Takami Yoshida, Takahiro Nishimura, Yohei Kawano, Yasunari Mano, Erina Shigematsu and Makoto Ujihara
    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:5
    Content type: Research article Published on:

  33. Few systematic reviews have examined the effects of sodium-glucose co-transporter 2 inhibitors (SGLT2is) on lipid profiles in Asian patients with type 2 diabetes mellitus. We conducted a systematic review with...

    Authors: Junichi Mukai, Ayano Yoshiyama and Rie Kubota
    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:4
    Content type: Research article Published on:

  34. Because cisplatin (CDDP) decreases upon light exposure, it is necessary to prevent such exposure during administration. However, the shielding conditions employed are not uniform. Therefore, in this study, we ...

    Authors: Tomoya Abe, Daigo Matsumoto, Toshiaki Nakayama, Yukinari Shimazaki, Atsunobu Sagara, Dan Kanehira, Takuya Azechi, Fumiaki Sato, Hiroyasu Sakai, Tetsuro Yumoto and Junzo Kamei
    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:3
    Content type: Short report Published on:

  35. Inappropriate dosing of direct oral anticoagulants (DOACs) has been associated with clinical safety and efficacy; however, little is known about clinical data associated with an inappropriate DOAC dosing in Ja...

    Authors: Motoyasu Miyazaki, Koichi Matsuo, Masanobu Uchiyama, Yoshihiko Nakamura, Yuya Sakamoto, Momoko Misaki, Kaoko Tokura, Shiro Jimi, Keisuke Okamura, Sen Adachi, Tomohiko Yamamoto, Kazuyuki Shirai, Hidenori Urata and Osamu Imakyure
    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:2
    Content type: Research article Published on:

  36. The clobetasol propionate cream formulations (CLBCr) belong to the “strongest” group, and are used widely. In addition, those formulations are often used as a mixture with moisturizer. Recently, we evaluated phar...

    Authors: Yoshihisa Yamamoto, Yoshinori Onuki, Toshiro Fukami and Tatsuo Koide
    Citation: Journal of Pharmaceutical Health Care and Sciences 2020 6:1
    Content type: Research article Published on:

  37. Sipuleucel-T, an autologous active cellular immunotherapy, is indicated for the treatment of asymptomatic or minimally symptomatic castration-resistant prostate cancer. The U.S. Food and Drug Administration Ad...

    Authors: Graça M. Dores, Silvia Perez-Vilar and Manette T. Niu
    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:27
    Content type: Short report Published on:

  38. Atropine eye drops are indicated for juvenile myopia progression, cycloplegia, amblyopia, and strabismus. According to the package insert, 10 mg/mL atropine eye drops must be diluted for pediatric patients to ...

    Authors: Jumpei Saito, Hitomi Imaizumi and Akimasa Yamatani
    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:25
    Content type: Research article Published on:

  39. Food is known to affect drug absorption by delaying gastric emptying time, altering gastrointestinal pH, stimulating bile flow, increasing splanchnic blood flow, or physically interacting with drugs. Although ...

    Authors: Fukiko Omachi, Masaki Kaneko, Ryosuke Iijima, Machiko Watanabe and Fumio Itagaki
    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:26
    Content type: Research article Published on:

  40. Cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP) regimen includes a high dose of prednisolone (100 mg/body), which exhibits an anticancer and antiemetic effect. However, its optimal use for ...

    Authors: Yoshinori Wakasugi, Satoshi Noda, Yoshihiro Ikuno, Miya Horie, Katsuyuki Kito, Hitoshi Minamiguchi and Tomohiro Terada
    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:24
    Content type: Research article Published on:

  41. Both polypharmacy and frailty are critical issues faced by the elderly. The decrease in gait speed is an index of frailty, and it is generally associated with falls and fractures, which are risk factors requir...

    Authors: Masataka Deguchi, Keigo Nishida, Tomoyuki Enokiya and Kazuya Ooi
    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:23
    Content type: Research article Published on:

  42. Multiple daily subcutaneous injections (MDSIs) are mainly used for formulating an insulin therapy for diabetic patients; however, they also cause insulin-derived amyloidosis (IDA) and lead to poor glycemic con...

    Authors: Yui Ohno, Tomohiro Seki, Yu Kojima, Ryotaro Miki, Yuya Egawa, Osamu Hosoya, Keizo Kasono and Toshinobu Seki
    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:22
    Content type: Research article Published on:

  43. Infliximab (IFX) has changed the management of many life-threatening immune-mediated diseases. The high cost of IFX and its patent expiry have led to pharmaceutical companies developing a biosimilar; however, ...

    Authors: Iku Niinomi, Keiko Hosohata, Yasuhiro Mori, Yuki Yamaguchi, Tomohito Wakabayashi, Mayako Uchida and Kazunori Iwanaga
    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:21
    Content type: Short report Published on:

  44. There is a lack of evidence that multidrug use triggers adverse events. Therefore, the main purpose of this study was to clarify the relationship between the total number of drugs and number of high-risk presc...

    Authors: Sayaka Arai, Takahiro Ishikawa, Hisaya Kato, Masaya Koshizaka, Yoshio Maezawa, Takako Nakamura, Takaaki Suzuki, Koutaro Yokote and Itsuko Ishii
    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:20
    Content type: Short report Published on:

  45. Chemotherapy is important for cancer treatment, but patients’ physical and mental stress may lead to unfavorable pain control, an increase in the risk of relapse, and a reduction in the quality of life (QOL). ...

    Authors: Chiaki Takagi, Saori Nakagawa, Naoto Hirata, Shin Ohta and Sadahiko Shimoeda
    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:18
    Content type: Research article Published on:

  46. According to the Clinical Practice Guidelines for Clostridioides difficile, oral vancomycin is to be used in vancomycin tapered and pulsed regimen (VCM-TP) for recurrent Clostridium difficile infection (CDI). How...

    Authors: Takumi Umemura, Aiko Ota, Yoshikazu Mutoh, Chihiro Norizuki, Takahito Mizuno, Koji Kozaki, Yoshiaki Ikeda and Toshihiko Ichihara
    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:19
    Content type: Short report Published on:

  47. Dabigatran is a direct thrombin inhibitor and an anticoagulant that is prescribed to prevent ischemic stroke and systemic embolism in non-valvular atrial fibrillation. Dabigatran (150 mg twice daily) is non-in...

    Authors: Yuuki Akagi, Tatsuo Chiba, Shusuke Uekusa, Hiroyoshi Kato, Shigeo Yamamura, Yukiko Aoki, Mizuho Enoki, Yuka Ogawara, Takanori Kasahara, Yuki Kimura, Tadahiro Shimizu, Aiko Takeishi, Yuko Nakajima, Hideki Kobayashi and Kaoru Sugi
    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:17
    Content type: Research article Published on:

  48. Oral mucositis is a frequent and severe adverse event in patients undergoing chemoradiotherapy for head and neck cancers, especially grade 3 or 4 mucositis. Occurrence may result in drop-out from treatment, th...

    Authors: Shinsuke Akagi, Takashi Fujiwara, Mai Nishida, Akiko Okuda, Yuka Nagao, Toshikatsu Okuda, Hidenori Tokuda and Kazunobu Takayanagi
    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:16
    Content type: Research article Published on:

  49. Despite the high mortality of patients with sepsis and carbapenem-resistant bacteria infection, appropriate antimicrobial therapies are yet to be established. Here, we have reported the case of a patient with ...

    Authors: Kazutaka Oda, Hidenobu Kamohara, Tomomi Katanoda, Yumi Hashiguchi, Koji Iwamura, Kisato Nosaka, Hirofumi Jono and Hideyuki Saito
    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:15
    Content type: Case report Published on:

  50. There is no nationwide data on polypharmacy in palliative care in Japan. In this study, the research committee of the Japanese Society for Pharmaceutical Palliative Care and Sciences conducted an online survey...

    Authors: Mayako Uchida, Shinya Suzuki, Hideki Sugawara, Yukio Suga, Hideya Kokubun, Yoshihiro Uesawa, Takayuki Nakagawa and Hisamitsu Takase
    Citation: Journal of Pharmaceutical Health Care and Sciences 2019 5:14
    Content type: Research article Published on:
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