Table 6 DDIs associated with comedications stratified by common comorbidities and HCV severity
Overall | SOF/VEL | GLE/PIB | ||||||
|---|---|---|---|---|---|---|---|---|
Congestive heart failure | With | Total | 1,382 | 111 | 1,271 | |||
DDIs | 1,045 | 75.6% | 75 | 67.6% | 970 | 76.3% | ||
DDIs > = 2 medications | 659 | 47.7% | 30 | 27.0% | 629 | 49.5% | ||
Without | Total | 5,956 | 356 | 5,600 | ||||
DDIs | 2,774 | 46.6% | 202 | 56.7% | 2,572 | 45.9% | ||
DDIs > = 2 medications | 1,055 | 17.7% | 36 | 10.1% | 1,019 | 18.2% | ||
Cerebrovascular disease | With | Total | 1,079 | 62 | 1,017 | |||
DDIs | 767 | 71.1% | 40 | 64.5% | 727 | 71.5% | ||
DDIs > = 2 medications | 435 | 40.3% | 13 | 21.0% | 422 | 41.5% | ||
Without | Total | 6,259 | 405 | 5,854 | ||||
DDIs | 3,052 | 48.8% | 237 | 58.5% | 2,815 | 48.1% | ||
DDIs > = 2 medications | 1,279 | 20.4% | 53 | 13.1% | 1,226 | 20.9% | ||
Chronic pulmonary disease | With | Total | 1,280 | 94 | 1,186 | |||
DDIs | 842 | 65.8% | 59 | 62.8% | 783 | 66.0% | ||
DDIs > = 2 medications | 432 | 33.8% | 15 | 16.0% | 417 | 35.2% | ||
Without | Total | 6,058 | 373 | 5,685 | ||||
DDIs | 2,977 | 49.1% | 218 | 58.4% | 2,759 | 48.5% | ||
DDIs > = 2 medications | 1,282 | 21.2% | 51 | 13.7% | 1,231 | 21.7% | ||
Peptic ulcer disease | With | Total | 1,491 | 145 | 1,346 | |||
DDIs | 1,053 | 70.6% | 113 | 77.9% | 940 | 69.8% | ||
DDIs > = 2 medications | 519 | 34.8% | 22 | 15.2% | 497 | 36.9% | ||
Without | Total | 5,847 | 322 | 5,525 | ||||
DDIs | 2,766 | 47.3% | 164 | 50.9% | 2,602 | 47.1% | ||
DDIs > = 2 medications | 1,195 | 20.4% | 44 | 13.7% | 1,151 | 20.8% | ||
Any malignancy, | With | Total | 1,612 | 190 | 1,422 | |||
including lymphoma and leukemia, | DDIs | 994 | 61.7% | 119 | 62.6% | 875 | 61.5% | |
except malignant neoplasm of skin | DDIs > = 2 medications | 444 | 27.5% | 29 | 15.3% | 415 | 29.2% | |
Without | Total | 5,726 | 277 | 5,449 | ||||
DDIs | 2,825 | 49.3% | 158 | 57.0% | 2,667 | 48.9% | ||
DDIs > = 2 medications | 1,270 | 22.2% | 37 | 13.4% | 1,233 | 22.6% | ||
Type of HCV | Decompensated cirrhosis | Total | 149 | 129 | 20 | |||
DDIs | 97 | 65.1% | 84 | 65.1% | 13 | 65.0% | ||
DDIs > = 2 medications | 27 | 18.1% | 19 | 14.70% | 8 | 40.0% | ||
Compensated cirrhosis | Total | 234 | 10 | 224 | ||||
DDIs | 131 | 56.0% | 4 | 40.0% | 127 | 56.7% | ||
DDIs > = 2 medications | 64 | 27.4% | 0 | 0.0% | 64 | 28.6% | ||
Chronic hepatitis C | Total | 5,963 | 247 | 5,716 | ||||
DDIs | 3,067 | 51.4% | 137 | 55.5% | 2,930 | 51.3% | ||
DDIs > = 2 medications | 1,377 | 23.1% | 32 | 13.0% | 1,345 | 23.5% | ||
Others | Total | 992 | 81 | 911 | ||||
DDIs | 524 | 52.8% | 52 | 64.2% | 472 | 51.8% | ||
DDIs > = 2 medications | 246 | 24.8% | 15 | 18.5% | 231 | 25.4% | ||