Fig. 2

A: Relation between VCM AUC and GM trough level. Horizontal dot line shows the guideline-recommended threshold of VCM AUC 600 mg∙h/mL. Vertical dot line shows threshold of GM level 1 µg/mL. B: Relation between VCM trough level and GM trough level. Horizontal dot line shows the guideline-recommended threshold of VCM trough level 15 µg/mL. Vertical dot line shows threshold of GM level 1 µg/mL. Closed circles show patients who developed AKI and treated with once daily administration of GM. Closed triangles show patients who developed AKI and treated with twice or three times daily administration of GM. Open circles show patients who did not develop AKI and treated with once daily administration of GM. Open triangles show patients who did not developed AKI and treated with twice or three times daily administration of GM. Abbreviations: AKI; acute kidney injury, AUC; area under the curve, GM; gentamicin, mono; monotherapy, VCM; vancomycin