Association of chemotherapy-induced nausea and vomiting or anorexia with plasma levels of five gastrointestinal peptides in patients receiving chemotherapy

Table 1 Patient characteristics and clinical laboratory data

Characteristics	All	CINV		P*	Anorexia		P*
Characteristics	n = 20	( +) n = 4	(-) n = 15	P*	( +) n = 7	(-) n = 10	P*
Age (year)	70.0 [68.8–72.8]	70.0 [69.8–71.3]	70.0 [68.5–73.5]	1.00	70.0 [69.0–76.0]	70.0 [68.5–71.0]	0.67
Sex (male/female)				0.35			0.44
Male	16 (80.0)	4 (100.0)	11 (73.3)		6 (85.7)	7 (70.0)
Female	4 (20.0)	0 (0.0)	4 (26.7)		1 (14.3)	3 (30.0)
Body weight (kg)	60.2 [53.7–65.2]	62.0 [57.0–63.8]	59.2 [53.3–64.4]	0.89	54.8 [50.9–61.2]	60.9 [54.6–64.8]	0.36
Serum albumin (g/dL)	3.7 [3.4–3.9]	3.7 [3.4–3.9]	3.7 [3.4–3.9]	0.89	3.4 [3.3–3.7]	3.9[3.6–4.0]	0.06
BUN (mg/dL)	12.6 [11.7–15.8]	12.2 [11.6–13.9]	13.4 [11.8–16.1]	0.81	12.5 [11.8–15.1]	13.0 [11.8–15.5]	0.89
Regimen				0.48			0.58
CDDP/5-FU	2 (10.0)	0 (0.0)	2 (13.3)		1 (14.3)	1 (10.0)
CDDP/5-FU + Radiation	8 (40.0)	3 (75.0)	5 (33.3)		4 (57.1)	3 (30.0)
CDDP + GEM	8 (40.0)	1 (25.0)	7 (46.7)		2 (28.6)	5 (50.0)
CDDP + BLM + ETP	2 (10.0)	0 (0.0)	1 (6.7)		0 (0.0)	1 (10.0)
Chemotherapy course				0.72			0.63
First chemotherapy course	8 (40.0)	2 (50.0)	6 (40.0)		2 (28.6)	4 (40.0)
Subsequent chemotherapy course	12 (60.0)	2 (50.0)	9 (60.0)		5 (71.4)	6 (60.0)

Data are expressed as numbers (%) for categorical variables and median [interquartile range] for continuous variables. Statistical differences between the groups were analyzed using chi-squared or Fisher's exact test for categorical variables and Mann–Whitney U test for continuous variables. CINV Chemotherapy-induced nausea and vomiting, BUN Blood urea nitrogen, CDDP Cisplatin, 5-FU 5-fluorouracil, GEM Gemcitabine, BLM Bleomycin, ETP Etoposide

ISSN: 2055-0294