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Table 2 Stepwise search for covariates in the final model of vancomycin concentrations

From: Development and validation of a population pharmacokinetic model of vancomycin for patients of advanced age

Model

Description

−2LL

Δ -2LL

AIC

n-parameter

1

Base model

2431.60

–

2445.60

7

2

Central clearance on estimated glomerular filtration rate unadjusted for body surface area

2355.51

76.09a

2371.51

8

3

Central clearance on estimated creatinine clearance

2331.23

100.37a

2347.23

8

4

Central clearance on estimated creatinine clearance and Serum albumin level

2326.11

5.11b

2344.11

9

  1. -2LL -2 log likelihood, AIC Akaike information criterion, eGFR estimated glomerular filtration rate unadjusted for body surface area, CLcr estimated creatinine clearance
  2. aCompared with model 1
  3. bCompared with model 3