Fig. 2

Validation of the final model. A and B. The height of the bars indicates the mean absolute prediction error (MAE) of CL and the dosage at 250 mg intervals achieving an area under the concentration–time curve at a steady state of 500, respectively. C and D. The height of the bars indicates the mean squared error (MSE) of CL and the dosage at 250 mg intervals achieving an area under the concentration–time curve at a steady state of 500, respectively. The grey and black bars represent patients aged ≥ 75 years and patients aged ≥ 75 years with an SCr of < 0.6 mg/dL, respectively. The error bars represent their corresponding 95% confidence intervals