Vancomycin dosing design method considering risk factors for nephrotoxicity

Table 1 Population pharmacokinetics parameters of VCM in Japanese adult patients used for bayesian estimation

Population pharmacokinetics	Interindividual variability
CL (mL/min) = 0.797 × CLcr	ω_CL = 38.5%
(CLcr ≤ 120 mL/min) ^†)
K₁₂ (h^− 1) = 0.525	ω_k12 = 50.0%
K₂₁ (h^− 1) = 0.213	ω_k21 = 28.6%
Vss (L) = 60.7	ω_Vss = 25.4%
	Intra-individual variability
	δ = 23.7%

CL: VCM creatinine clearance, k₁₂ and k₂₁: transter rate constants, Vss: steady-state volume of distribution
^†) The restriction of CLcr > 85 mL/min was changed to 120 mL/min and applied

ISSN: 2055-0294