Table 3 Pharmacokinetic parameters of fentanyl after intravenous and transdermal administration in GK and Wistar rats
Wistar rats | GK rats | |
|---|---|---|
Intravenous administration | ||
\({AUC}_{0-\infty }\) (ng・hr/mL) | 3.12 ± 0.16 | 3.22 ± 0.44 |
\({CL}_{\text{tot}}\) (L/hr/kg) | 3.21 ± 0.17 | 3.15 ± 0.42 |
\({k}_{\text{e}}\times {10}^{-1}\) (/hr) | 2.79 ± 0.26 | 2.55 ± 0.34 |
\({Vd}_{\text{ss}}\) (L/kg) | 6.49 ± 0.32 | 6.94 ± 1.77 |
Transdermal administration | ||
\({C}_{\text{max}}\) (ng/mL) | 4.74 ± 2.32 | 4.40 ± 0.86 |
\({T}_{\text{max}}\) (hr) | 9.60 ± 2.19 | 4.80 ± 1.79* |
\({AUC}_{0-\infty }\) (ng・hr/mL) | 88.6 ± 27.5 | 87.9 ± 12.5 |
\({CL}_{\text{tot}}/F\) (L/hr/kg) | 6.51 ± 1.90 | 5.68 ± 0.81 |
\({k}_{\text{a}}\times {10}^{-2}\) (/hr) | 2.28 ± 0.67 | 3.17 ± 0.30* |
\(F\) (%) | 53.0 ± 16.3 | 55.5 ± 7.1 |
\({F}_{a}\) (%) | 69.0 ± 6.3 | 78.0 ± 5.8* |
\({F}_{skin}\) (%) | 76.3 ± 20.1 | 71.4 ± 10.5 |