Table 2 Logistic regression analysis related to the titration period of 6 days or more

Female

0.852

0.548

1.324

0.477

N/A

N/A

Age

1.007

0.989

1.025

0.460

N/A

N/A

BMI

0.955

0.897

1.016

0.146

N/A

N/A

Serum albumin^a

0.977

0.723

1.320

0.879

N/A

N/A

Initial dose

1.029

0.771

1.375

0.845

N/A

N/A

Comorbidities^b (ICD-10 code)

Malignant neoplasm of bladder (C67)

5.059

1.286

19.905

0.020

3.831

0.854

17.176

0.079

Secondary malignant neoplasm of other and unspecified digestive organs (C78.8)

3.554

0.836

15.113

0.086

2.009

0.401

10.056

0.396

Secondary malignant neoplasm of bone and bone marrow (C79.5)

1.584

0.938

2.677

0.085

1.563

0.890

2.745

0.120

Secondary malignant neoplasm of adrenal gland (C79.7)

3.779

1.085

13.159

0.037

2.475

0.610

10.047

0.205

Myeloid leukaemia (C92)

8.525

0.943

77.076

0.056

6.771

0.595

77.025

0.123

Other hypothyroidism (E03)

3.012

0.937

9.685

0.064

2.635

0.766

9.061

0.124

Unspecified diabetes mellitus (E14)

0.451

0.236

0.863

0.016

0.438

0.217

0.884

0.021

Unspecified dementia (F03)

8.525

0.943

77.076

0.056

8.415

0.882

80.257

0.064

Aortic aneurysm and dissection (I71)

4.300

1.057

17.485

0.042

4.590

1.008

20.905

0.049

Other diseases of digestive system (K92)

4.246

0.767

23.498

0.098

4.040

0.649

25.147

0.134

Other spondylopathies (M48)

4.300

1.057

17.485

0.042

3.055

0.652

14.322

0.157

Hyperplasia of prostate (N40)

4.246

0.767

23.498

0.098

4.241

0.672

26.765

0.124