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Fig. 4 | Journal of Pharmaceutical Health Care and Sciences

Fig. 4

From: Effect of changes in skin properties due to diabetes mellitus on the titration period of transdermal fentanyl: single-center retrospective study and diabetic animal model study

Fig. 4

Plasma fentanyl concentration after intravenous and transdermal administration in GK and Wistar rats. Fentanyl citrate injection (10 µg/kg body weight as fentanyl) was administered intravenously to GK (open circle) and Wistar (closed circle) rats (A). Fentanyl citrate formulation (160 µg as fentanyl) was applied to the lateral abdominal skin and the formulation was removed at 24 h (B). Data are expressed as mean ± S.D. (n = 5)

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