Fig. 1

Flowchart of analysis in the retrospective study. In total, 733 patients were enrolled, and 387 patients were analyzed. Among them 261 patients showed a titration period of within 5 days, and 261 showed a titration period of 6 days or more. ^a Inducers or inhibitors of CYP3A4 used in excluded patients were as follows: carbamazepine, enzalutamide, mitotane, phenobarbital, phenytoin, rifampicin, amiodarone, cobicistat, clarithromycin, diltiazem, fluvoxamine, indinavir, itraconazole, nelfinavir, saquinavir, ritonavir, and voriconazole