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Table 1 List of strong opioid injectable drugs available in Japan

From: Comparison of continuous subcutaneous hydromorphone hydrochloride and morphine hydrochloride injection on skin disorders incidence: a retrospective study

Drug name

Osmotic pressure (approximately)

pH

Daily dosage when continuously administered at 0.1 mL/h without dilution (Dosage converted to morphine hydrochloride injection)

4% Morphine

Hydrochloride [13]

0.6

2.5–5.0

96 mg/day (96 mg/day)

1% Morphine

Hydrochloride [14]

0.2

2.5–5.0

24 mg/day (24 mg/day)

1% Oxycodone

Hydrochloride [15]

1.0

4.5–5.5

24 mg/day (24 mg/day)

0.005% Fentanyl citrate [16, 17]

0.01

1

4.5–6.5

3.9–5.9

0.12 mg/day (6 mg/day)

0.2% Hydromorphone hydrochloride [18]

1.0

3.5–4.5

4.8 mg/day (38.4 mg/day)

1% Hydromorphone hydrochloride [18]

1.0

3.5–4.5

24 mg/day (192 mg/day)

  1. The conversion ratio of each opioid injection is morphine: oxycodone: fentanyl: hydromorphone = 200: 200: 4: 25 from the Guidelines for the Pharmacotherapy of Cancer Pain [8]