Table 4 Intervention outcomes for clinical endpoints

Clinical efficacy

Effective

80 (65%)

99 (71%)

P = 0.35^a

Not effective

30 (24%)

29 (21%)

Unnecessary use

13 (11%)

12 (8.6%)

Adverse events

Renal impairment^b

13 (11%)

17 (12%)

P = 0.85

Discontinuation due to adverse events

6 (4.9%)

10 (7.1%)

P = 0.61

Kidney injury

5 (4.1%)

3 (2.1%)

P = 0.48

Ototoxicity

0 (0%)

1 (0.7%)

P = 1.00

Skin rash

0 (0%)

2 (1.4%)

P = 0.50

Hepatic injury

0 (0%)

2 (1.4%)

P = 0.50

Diarrhea

1 (0.8%)

0 (0%)

P = 0.47

Loss of appetite

0 (0%)

1 (0.7)

P = 1.00

Death

6 (4.9%)

5 (3.6%)

P = 0.76