Development and validation of the prediction score for augmented renal clearance in critically Ill Japanese adults

Table 1 Clinical characteristics

	Total (n = 651)	Training set (n = 456)	Validation set (n = 195)	p-value
Age, years^a	71 (57–80)	71 (58–80)	70 (55–79)	0.337
Male sex^b	383 (59%)	266 (58%)	117 (60%)	0.692
Weight, kg^a	57 (48–67)	57 (47–66)	59 (49–69)	0.081
Body surface area, m^2a	1.59 (1.44–1.73)	1.58 (1.42–1.72)	1.62 (1.48–1.76)	0.066
SCr, mg/dL^a	1.05 (0.78–1.49)	1.05 (0.76–1.49)	1.06 (0.83–1.48)	0.410
Admission diagnosis^b
Trauma	90 (14%)	65 (14%)	25 (13%)	0.627
CNS^c	88 (14%)	60 (13%)	28 (14%)	0.681
Sepsis	68 (10%)	35 (8%)	33 (17%)	< 0.01
Cardiovascular	244 (38%)	182 (40%)	62 (32%)	0.050
Digestive	36 (6%)	23 (5%)	13 (7%)	0.407
Infection (without sepsis)	71 (11%)	48 (11%)	23 (12%)	0.634
Other	89 (14%)	68 (15%)	21 (11%)	0.159
SOFA score^a	5 (3–8)	5 (3–8)	4 (3–8)	0.130
ICU-free days^a	21 (11–24)	21 (11–24)	21 (12–24)	0.329
Mortality^b	90 (14%)	57 (13%)	33 (17%)	0.134

SCr serum creatinine, CNS central nervous system, SOFA sequential organ failure assessment, ICU intensive care unit
^aMedian (interquartile range)
^bNumber (%)
^cCNS refers to hospitalization for any of the following reasons: traumatic brain injury, intracerebral hemorrhage, subarachnoid hemorrhage, cerebral arteriovenous malformation, hydrocephalus, or status epilepticus

ISSN: 2055-0294