In-vivo evaluation of analgesic and anti-inflammatory activities of the 80% methanol extract of Acacia seyal stem bark in rodent models

Table 2 Effects of 80% methanolic stem bark extracts of A seyal in hotplate test in Mice

Mean latency time (Sec) and percentage of elongation
Groups	0 min	30 min		60 min		90 min		120 min
		Mean Latency	%	Mean Latency	%	Mean Latency	%	Mean Latency	%
DW10	3.67 ± 0.21	2.67 ± 0.49		2 ± 0.25		2 ± 0.36		1.83 ± 0.31
MRP10	2.67 ± 0.28	12.50 ± 0.75 a²b²c²	78.64	5.33 ± 0.61 a¹	62.47	8.67 ± 1.38 a²	6.93	9.33 ± 0.49 a²	80.38
ASME100	5.33 ± 1.02	7.83 ± 0.60 a²	65.90	3.50 ± 0.67	42.85	4.67 ± 0.67	57.17	6.00 ± 0.68	69.50
ASME200	4.67 ± 0.71	8.17 ± 0.79 a²	67.32	4.83 ± 0.70	58.59	6.00 ± 0.97 a¹	66.67	7.17 ± 0.47 a²	74.47
ASME400	4.50 ± 0.84	8.67 ± 0.61 a²	69.20	6.17 ± 1.35 a¹	67.58	7.50 ± 0.76 b²	73.33	7.83 ± 1.18 a²	76.62

Notes Each value represents mean ± S.E.M; n = 6 for each treatment; Analysis was performed by one way ANOVA; a, compared to negative control group; b, compared to ASME100; c, compared to ASME200;¹P<0.05;²P<0.001. Numbers followed by MRP and ASME indicate dose in mg/kg
Abbreviation: MRP, morphine; DW, distilled water; ASME, A. seyal methanolic extract

ISSN: 2055-0294