Influence of loop diuretics on denosumab-induced hypocalcaemia in osteoporosis: a retrospective observational analysis

Table 3 Multivariate logistic regression analysis of denosumab-induced hypocalcaemia

	OR	95% CI	P value
Body mass index, per kg/m²	0.848	0.701 to 1.024	0.0870
eGFR^a, per mL/min/1.73m²	0.992	0.972 to 1.012	0.4166
Corrected calcium^b, per mg/dL	0.032	0.005 to 0.209	< 0.0001
Calcium and vitamin D supplements^c, yes	0.285	0.094 to 0.868	0.0270
Loop diuretics, yes	6.410	1.005 to 40.90	0.0494

Hypocalcaemia was defined as a serum calcium level < 8.5 mg/dL [12]
Abbreviations: OR Odds ratio, 95% CI 95% confidence interval, eGFR estimated glomerular filtration rate
^aeGFR was estimated using the following Equation [15]
\(eGRF\;=194\times serum\;creatinine^{-1.094}\times age^{-0.287}\times0.739\;\left(if\;female\right)\)
^bSerum calcium level was corrected when serum albumin level <4.0 g/dL [13]
\(\mathrm{Corrected}\;\mathrm{calcium}\;=\;\mathrm{serum}\;\mathrm{calcium}\;+\;(4.0\;-\;\mathrm{serum}\;\mathrm{albumin})\)
^cDenotas^® (Daiichi Sankyo, Tokyo, Japan)

ISSN: 2055-0294