Fig. 4

Classification of AST and ALT levels using reference values. AST or ALT pre- and 12 months post-SGLT2i treatment were classified as below ULN (AST: ≤ 38 IU/L, ALT: male ≤ 44, female ≤ 23), Grade 1 (38 < AST ≤ 114, male: 44 < ALT ≤ 132, female: 23 < ALT ≤ 69), Grade 2 (114 < AST ≤ 190, male: 132 < ALT ≤ 220, female: 69 < ALT ≤ 115), and Grade 3 (190 < AST ≤ 760, male: 220 < ALT ≤ 880, female: 115 < ALT ≤ 460) according to the severity classification of CTCAE ver5.0