Table 3 Classification of concomitant medications that have DDIs with NMV-r under the recommended DDI management

Consider alternative COVID-19 therapy

68

7

61

 Immunosuppressants

Tacrolimus

25

1

24

Cyclosporine

7

0

7

Everolimus

5

0

5

 Antiepileptics

Clonazepam

6

1

5

Clobazam

2

0

2

Carbamazepine^a

1

0

1

 Anticoagulants

Warfarin

5

2

3

Rivaroxaban^a

4

1

3

 Vasopressin antagonists

Tolvaptan

4

0

4

 Antineoplastic and immunomodulating agents

Nilotinib

1

1

0

Tamoxifen

1

0

1

Toremifene

1

0

1

 Antiplatelet agents

Clopidogrel

2

0

2

Cilostazol

1

1

0

 Antiarrhythmics

Amiodarone^a

1

0

1

Bepridil^a

1

0

1

 Antimycobacterials

Rifampicin^a

1

0

1

Temporary withhold/reduction/alteration of concomitant medication

184

62

122

 Calcium channel blockers

Amlodipine

48

19

29

Nifedipine

14

3

11

Diltiazem

2

1

1

Verapamil

1

0

1

 HMG-CoA reductase inhibitors

Rosuvastatin

19

4

15

Atorvastatin

17

7

10

 Hypnotics and sedatives

Etizolam

8

5

3

Suvorexant^a

6

1

5

Brotizolam

5

3

2

Lenborexant

3

0

3

Alprazolam

2

1

1

Triazolam^a

1

0

1

 Anticoagulants

Edoxaban

7

1

6

Apixaban

3

0

3

Dabigatran

1

1

0

 Alpha-adrenoreceptor antagonists

Tamsulosin

4

2

2

Silodosin

3

1

2

 Antidepressants

Trazodone

6

0

6

 Antipsychotics

Aripiprazole

4

0

4

Quetiapine

2

0

2

 Antigout agents

Colchicine^a

5

1

4

Antihistamines

Fexofenadine

4

0

4

Lupatadine

1

1

0

 Aldosterone antagonists

Eplerenone^a

5

2

3

 Opioids

Oxycodone

3

2

1

Fentanyl

1

0

1

 Phosphodiesterase-5 Enzyme Inhibitors

Tadalafil

2

1

1

 Antibacterials

Clarithromycin

2

2

0

 Corticosteroids

Dexamethasone

2

1

1

 Antipropulsives

Loperamide

2

2

0

 Antimigraine agents

Eletriptan^a

1

1

0

Continuation of concomitant medication (monitoring the effects/adverse effects of each medication)

13

6

7

 Opioids

Tramadol

5

1

4

 Antifungals

Fluconazole

4

4

0

 Antiepileptics

Valproic acid

2

0

2

 Antivirals for the treatment of HIV infections

BIC/TAF/FTC

1

1

0

Darunavir

1

0

1