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Table 2 Actual management practices of DDIs in the NMV-r group according to the recommended DDI management

From: Evaluation of the drug-drug interactions management system for appropriate use of nirmatrelvir/ritonavir: a retrospective observational study

Actual DDI management practices according to the recommended DDI management

n (%)

Total

126

(a) Patients with reduced renal function (eGFR < 30 mL/min/1.73m2)

0

(b) Patients with insufficient details on concomitant medications

0

(c) Patients with concomitant medications categorized as “consider alternative COVID-19 therapy other than NMV-r”

7

 Temporary withhold/reduction/alteration of concomitant medications

6 (85.7%)

 Details of management were unknown

1 (14.3%)

(d) Patients with concomitant medications categorized as “temporary withhold/reduction/alteration of concomitant medication”

44

 Temporary withhold/reduction/alteration of concomitant medications

42 (95.5)

 Continuation of concomitant medication (monitoring the effects/adverse effects of each medication)

2 (4.5)

(e) Patients with concomitant medications categorized as “continuation of concomitant medication (monitoring the effects/adverse effects of each medication)”

4

 Temporary withhold/reduction/alteration of concomitant medications

3 (75.0)

 Continuation of concomitant medication (monitoring the effects/adverse effects of each medication)

1 (25.0)

(f) Patients without concomitant medications requiring DDI management

71

 Temporary withhold/reduction/alteration of concomitant medications

3 (4.2)

 No management for DDIs

68 (95.8)

  1. COVID-19 the coronavirus disease 2019, DDI drug-drug interactions, eGFR estimated glomerular filtration rate, NMV-r nirmatrelvir/ritonavir