Characteristics of CYP3A4-related potential drug-drug interactions in outpatients receiving prescriptions from multiple clinical departments

Table 3 Factors associated with an increase in the number of drugs involved in CYP3A4-related potential DDIs

	B	SE	b	t-value	p-value	VIF
Age	-0.004	0.005	-0.030	-0.737	0.461	1.316
Sex (0: male, 1: female)	-0.270	0.142	-0.076	-1.905	0.058	1.255
Number of clinical departments	0.235	0.157	0.059	1.499	0.135	1.215
Agents affecting central nervous system	0.425	0.047	0.352	9.038	< 0.01*	1.200
Agents affecting peripheral nervous system	-0.443	0.332	-0.049	-1.335	0.183	1.063
Agents affecting sensory organs	-0.052	0.262	-0.007	-0.200	0.842	1.037
Cardiovascular agents	0.515	0.048	0.450	10.847	< 0.01*	1.362
Respiratory organ agents	0.104	0.139	0.029	0.753	0.452	1.209
Digestive organ agents	0.247	0.058	0.168	4.250	< 0.01*	1.230
Hormones	0.280	0.172	0.061	1.631	0.104	1.121
Urogenital and anal organ agents	0.861	0.113	0.330	7.603	< 0.01*	1.493
Vitamins	-0.123	0.097	-0.049	-1.275	0.203	1.179
Nutrients, tonics	0.063	0.298	0.008	0.212	0.832	1.094
Blood and body fluid agents	0.623	0.161	0.149	3.868	< 0.01*	1.169
Other agents affecting metabolism	0.309	0.058	0.209	5.289	< 0.01*	1.231
Antineoplastics	0.366	0.295	0.045	1.243	0.215	1.054
Allergic agents	0.543	0.113	0.198	4.808	< 0.01*	1.348
Traditional Chinese medicines	-0.284	0.257	-0.040	-1.102	0.271	1.054
Antibiotics	0.585	0.250	0.095	2.345	0.020*	1.292
Chemotherapeutics	0.533	0.508	0.039	1.051	0.294	1.079
Alkaloidal narcotics	1.180	0.548	0.078	2.152	0.032*	1.052

DDIs Drug-drug interactions, B Partial regression coefficient, SE Standard error, b Standardized partial regression coefficient, VIF Variance inflation factor
^*P < 0.05

ISSN: 2055-0294