Table 2 Incidence of CYP3A4-related potential DDIs by number of drugs taken

Number of patients

less than 6

516

128

6 or more

128

244

Number of drugs taken

less than 6

3.0 ± 1.0

4.3 ± 0.8

 < 0.01*^{, a}

6 or more

7.5 ± 1.7

8.7 ± 2.4

 < 0.01*^{, a}

Number of drugs involved CYP3A4-related potential DDIs

less than 6

1.4 ± 1.0

2.1 ± 1.2

 < 0.01*^{, a}

6 or more

3.5 ± 1.6

4.0 ± 1.7

 < 0.01*^{, a}

Incidence of CYP3A4-related potential DDI due to two or more drugs

less than 6

43.2%

71.1%

 < 0.01*^{, b}

6 or more

89.8%

94.7%

0.090^b

Incidence of CYP3A4-related potential DDI due to three or more drugs

less than 6

13.6%

35.2%

 < 0.01*^{, b}

6 or more

74.2%

81.2%

0.142^b