Hyperkalemic effect of drug–drug interaction between esaxerenone and trimethoprim in patients with hypertension: a pilot study

Table 2 Summary of outcomes

	n	Before	After	Δ	P value (Before vs after)	P value (Between groups)
K, meq/L
ESA alone	8	4.4 [4.2 to 4.7]	5.2 [4.7 to 5.4]	0.6 [0.3 to 0.9]	0.008	0.342
ESA+TMP	8	4.2 [4.0 to 5.1]	5.4 [4.7 to 5.5]	1.0 [0.4 to 1.3]	0.023
Na, meq/L
ESA alone	8	140 [139 to 143]	141 [139 to 142]	-1 [-2 to 1]	0.375	0.749
ESA+TMP	8	141 [139 to 143]	141 [138 to 143]	-1 [-3 to 1]	0.266
BUN, mg/dL
ESA alone	8	25.1 [21.0 to 30.5]	30.5 [23.0 to 33.9]	5.7 [-0.7 to 7.0]	0.055	0.674
ESA+TMP	8	21.2 [17.4 to 26.6]	28.5 [19.0 to 34.3]	4.1 [-0.5 to 11.0]	0.109
Cr, mg/dL
ESA alone	8	1.29 [1.00 to 1.82]	1.65 [1.03 to 2.17]	0.23 [0.02 to 0.45]	0.039	0.752
ESA+TMP	8	1.00 [0.74 to 1.31]	1.31 [0.76 to 1.60]	0.20 [-0.03 to 0.43]	0.086
eGFR, mL/min/1.73m²
ESA alone	8	38.9 [27.8 to 45.4]	31.2 [23.4 to 41.0]	-3.4 [-8.3 to -0.9]	0.039	0.401
ESA+TMP	8	50.9 [38.8 to 63.3]	40.1 [30.0 to 60.9]	-9.8 [-14.7 to 1.4]	0.055

Abbreviations: K potassium, Na sodium, BUN blood urea nitrogen, Cr creatinine, eGFR estimated glomerular filtration rate, ESA esaxerenone, TMP trimethoprim
Data are presented as the median [interquartile range]. Data are compared using the Mann–Whitney U test (between groups) or Wilcoxon signed-rank test (before vs. after)
\(\Delta =\text{maximum value}-\text{baseline value}\)
The maximum value is at the observation of the maximum potassium value
\(\text{eGFR }\left(\text{mL}/\text{min}/{1.73\text{m}}^{2}\right)=194\times {\text{age}}^{-0.287}\times {\text{serum creatinine}}^{-1.094}\times 0.739 \left(\text{if female}\right)\) [10]

ISSN: 2055-0294