Table 1 Comparison of demographic and clinical characteristics of study participants between once-daily dosing and multiple daily dosing groups
Initial daily dosing of gentamicin | P value | ||
|---|---|---|---|
Once daily (n = 22) | Multiple daily (n = 13) | ||
Sex, Male | 18 (82%) | 7 (54%) | 0.123 |
Age (years) | 72 (60, 77) | 67 (56, 75) | 0.384 |
Weight (kg) | 51.8 (43.4, 56.9) | 54.9 (47.0, 58.1) | 0.433 |
BMI (kg/m2) | 19.8 (16.4, 22.3) | 21.3 (19.6, 22.6) | 0.167 |
Treatment of gentamicin | |||
Initial daily dosage (mg/kg) | 2.80 (2.30, 4.34) | 2.96 (2.40, 3.20) | 0.966 |
Duration of administration (days) | 11 (7.5, 13) | 15 (15, 22) | 0.001 |
Days to initial trough measurement (days) | 4 (3, 5) | 4 (3, 5) | 0.941 |
Renal function | |||
Baseline serum creatinine (mg/dL) | 0.75 (0.56, 0.88) | 0.72 (0.56, 0.99) | 0.768 |
Baseline eGFR (mL/min/1.73m2) | 73.0 (66.0, 104.5) | 80.0 (67.0, 102.0) | 0.781 |
Drugs at risk for renal impairment | |||
Loop diuretics | 9 (41%) | 5 (38%) | 1.000 |
NSAIDs | 5 (23%) | 7 (54%) | 0.079 |