Table 7 Factors associated with poor TTR among patients receiving warfarin therapy
Variable | TTR ≥ 65% | TTR < 65% | COR (95%CI) | AOR (95%CI) | P-value |
|---|---|---|---|---|---|
Treatment group | |||||
 UMC | 111(21.1) | 239(45.5) | 1.00 | 1.00 | 0.01* |
 PLAC | 73(13.9) | 102(19.4) | 0.65(0.45,0.95) | 0.57(0.36,0.88) |  |
Sex | |||||
 Female | 132(25.1) | 243(46.3) | 1.00 | 1.00 | 0.79 |
 Male | 52(9.9) | 98(18.7) | 1.02(0.69,1.52) | 0.95(0.62,1.44) |  |
Age in years | Â | ||||
 18–30 | 32(6.1) | 75(14.3) | 1.00 | 1.00 |  |
 31–45 | 81(15.4) | 150(28.6) | 0.79(0.48,1.29) | 0.79(0.47,1.32) | 0.36 |
 46–64 | 53(10.1) | 82(15.6) | 0.66(0.39,1.13) | 0.57(0.32,1.02) | 0.06 |
 ≥ 65 | 18(3.4) | 34(6.5) | 0.81(0.39,1.63) | 0.45(0.19,1.03) | 0.06 |
HAS-BLED risk scores | |||||
 No risk | 65(12.4) | 125(23.8) | 1.00 | 1.00 |  |
 Low risk | 46(8.8) | 34(6.5) | 0.38(0.23, 0.66) | 0.51(0.29,0.91) | 0.02* |
 Moderate risk | 65(12.4) | 153(29.1) | 1.22(0.81,1.86) | 1.68(1.07,2.64) | 0.03* |
 High risk | 8(1.5) | 29(5.5) | 1.89(0.82,4.36) | 3.08(1.17,8.09) | 0.02* |
Post-mechanical heart valves | |||||
 No | 163(31.0) | 278(53.0) | 1.00 | 1.00 | 0.01* |
 Yes | 21(4.0) | 63(12.0) | 1.76(1.04,2.99) | 2.11(1.17,3.81) |  |
Post PMTC valvotomy | |||||
 No | 169(32.2) | 329(62.7) | 1.00 | 1.00 | 0.09 |
 Yes | 15(2.9) | 12(2.3) | 0.41(0.19,0.89) | 0.49(0.22,1.13) |  |
INR monitoring interval | Â | Â | 0.99(0.98,1.01) | 0.98(0.97,0.99) | 0.002* |