Table 1 Effect of physical impact on the D50 and adhesion of excipients to heat seal for ODP

Lactose

115 ± 0.063

107 ± 0.059

192 ± 0.0104

190 ± 0.0108

SP

30 ± 0.015^*

29 ± 0.013^*

137 ± 0.0299^*

141 ± 0.0278^*

HPC-30-SG

0.75%

100 ± 0.081^*

70 ± 0.045^*

165 ± 0.0182^*

163 ± 0.0179^*

1.5%

255 ± 0.133^*

165 ± 0.010^*

188 ± 0.0077

187 ± 0.0076

3%

130 ± 0.113^*

110 ± 0.084

190 ± 0.0102

189 ± 0.0101

HPC-80-SG

0.75%

140 ± 0.076^*

85 ± 0.041^*

156 ± 0.0166^*

153 ± 0.0163^*

1.5%

220 ± 0.122^*

195 ± 0.101^*

190 ± 0.0093

191 ± 0.0090

3%

110 ± 0.108^*

95 ± 0.052^*

192 ± 0.0081

191 ± 0.0082