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Table 2 Associations between parameters and discontinuation of TDF

From: Association between tenofovir plasma trough concentrations in the early stage of administration and discontinuation of up to five years tenofovir disoproxil fumarate due to renal function-related adverse events in Japanese HIV-1 infected patients

 

Univariate results

Multivariate results

OR

95%CI

p-value

OR

95%CI

p-value

Age ≧ 50

5.73

2.20–14.9

0.0004

2.96

1.01–8.64

0.0481

Body Weight ≦ 60 kg

2.06

0.950–4.50

0.0784

2.13

0.825–5.81

0.1184

eGFR ≦ 80(mL/min/1.73m3)

5.15

2.02–13.2

0.0008

5.51

1.83–17.5

0.0025

TFV trough ≧ 98 ng/mL

4.48

1.97–10.2

0.0005

2.96

1.16–7.60

0.0236

  1. OR odds ratio, CI confidence interval, eGFR estimated glomerular filtration rate, TFV tenofovir
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Journal of Pharmaceutical Health Care and Sciences

ISSN: 2055-0294

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