Fig. 1

A) Change in eGFR (mean ± SD) over 288 weeks in HIV-positive individuals who switched from TDF to antiretroviral therapy including TAF and continued taking it. B Change in eGFR (mean ± SD) over 288 weeks in each group classified by eGFR level at the time of switching from TDF to TAF (week 0, TAF0). In both (A) and (B), paired t-tested was performed at 48 weeks (TAF48), 96 weeks (TAF96), 144 weeks (TAF144), 192 weeks (TAF192), 240 weeks (TAF240), and 288 weeks (TAF288), using TAF0 as the reference, with a significance level of p < 0.05. The sample size of B) at each survey from TAF0 to TAF288 was 13 in group G1, 37 in group G2, and 10 in groups G3a, b. At TDF0, there were 8 in group G1, 32 in group G2, and 9 in groups G3a, b