Fig. 5
Percutaneous absorption profiles (A), AUCplasma (B), and FEL amount in the skin (C) treated with FEL ointment and gel. The percutaneous absorption and drug amount in the skin were measured in 7-weeks-old Wister rats. n = 8. * P < 0.05, vs. FEL-MP gel for each category. #P < 0.05, vs. CA-FEL ointment for each category. The percutaneous absorption and drug content in the skin treated with FEL-NP gels were significantly enhanced. The AUCplasma of FEL-NP gels was 1.52- and 1.38-fold that of CA-FEL ointment and FEL-MP gel, respectively. Moreover, the FEL content in the rat skin treated with FEL-NP gels was 1.38- and 2.54-fold higher than that of CA-FEL ointment and FEL-MP gels, respectively, after 24 h of treatment