Fig. 1

Measured (plots) and estimated (lines) plasma concentrations of duloxetine (a), flunitrazepam (b), quetiapine (c), and trazodone (d) in a patient who took a single oral overdose of these drugs. The patient took a single excessive oral dose of duloxetine (780 mg), flunitrazepam (18 mg), quetiapine (850 mg), and trazodone (1100 mg) in combination. The modeled plasma concentration curves after virtual administrations (solid lines) are shown with 95% confidence intervals (broken lines) based on the hepatic intrinsic clearance values shown in Table 2