Fig. 1

Plasma concentration-time profiles of LZD after intravenous and oral administration with and without RFP. a Plasma concentration-time profiles of LZD after intravenous administration of LZD (45.7 mg/kg) to rats with (closed circles) and without (open circles) RFP pretreatment (10 mg/kg) for four days. b Plasma concentration-time profiles of LZD after oral administration of LZD (62.5 mg/kg) to rats with (closed circles) and without (open circles) RFP pretreatment (10 mg/kg) for four days. Values are mean ± SD of three to six rats. *p < 0.05