Fig. 3

Relationships between fluconazole clearance normalized to body weight (BW) (CL_BW) and postmenstrual age (PMA) in neonates and infants (a) and between fluconazole CL_BW and age in children older than 5 years and adults (b). The area of each symbol (○) is in proportion to the number of datasets. There is a significant correlation between fluconazole CL_BW and PMA in neonates and infants (Y = 0.011X – 0.04, r = 0.46, p < 0.005), and between fluconazole CL_BW and age in young children and adults (Y = − 0.006X + 0.50, r = − 0.60, p < 0.001). Solid lines represent the least square regression lines. Bold dotted lines represent the upper and lower 95% confidence intervals of the regression lines. Fine dotted lines represent the 95% confidence intervals of all datasets