Fig. 2

Relationship between fluconazole clearance normalized to body surface area (BSA) (CL_BSA) and postmenstrual age (PMA) in neonates and infants (a) and between fluconazole CL_BSA and age in children older than 5 years and adults (b). The area of each symbol (○) is in proportion to the number of dataset. BSA of premature infants and neonates was estimated by Haycock’s formula, and that of children and adults by Dubois’s formula. There is a significant correlation between fluconazole CL_BSA and PMA in neonates and infants (Y = 0.263X -4.92, r = 0.68, p < 0.001), and between fluconazole CL_BSA and age in young children and adults (Y = − 0.097X + 14.22, r = − 0.36, p < 0.005). Solid lines represent the least square regression lines. Bold dotted lines represent the upper and lower 95% confidence intervals of the regression lines. Fine dotted lines represent the 95% confidence intervals of all datasets