Analysis of Stevens-Johnson syndrome and toxic epidermal necrolysis using the Japanese Adverse Drug Event Report database

Table 3 Quartile and parameter of Weibull distribution and failure pattern for each drugs

Drugs	Case reports	Median (day)	Lower quartile (day)	Upper quartile (day)	Minimum (day)	Maximum (day)	Scale parameter			Shape parameter
Drugs	Case reports	Median (day)	Lower quartile (day)	Upper quartile (day)	Minimum (day)	Maximum (day)	α	95 % CI		β	95 % CI
Allopurinol	281	21	12	35	0	1689	45.66	37.23	55.85	0.62	0.58	0.67
Loxoprofen	340	3	1	8	0	708	9.44	7.74	11.49	0.64	0.59	0.69
Acetaminophen	310	2	1	5	0	191	6.17	5.17	7.35	0.74	0.68	0.81
Carbamazepine	270	19	12	33	0	451	31.20	27.52	35.32	1.02	0.94	1.10
Lamotrigine	465	27	14	37	0	962	46.66	40.66	53.49	0.71	0.67	0.75
Phenytoin	117	20	11	29	1	1109	30.46	23.76	38.92	0.79	0.70	0.88
Furosemide	57	17	9	45	2	434	34.14	23.32	49.30	0.75	0.62	0.91
ACE inhibitors^a	47	20	6	33	0	227	38.02	25.62	55.48	0.81	0.65	1.00
Corticosteroids^b	89	19	11	26	0	206	25.01	20.56	30.30	1.17	1.00	1.35

^aIt containd 6 drugs; imidapril hydrochloride, enalapril maleate, temocapril hydrochloride, lisinopril hydrate, perindopril erbumine, and alacepril
^bIt containd 11 drugs; dexamethasone, dexamethasone sodium phosphate, dexamethasone acetate, triamcinolone acetonide, prednisolone, prednisolone acetate, betamethasone, betamethasone/d-chlorpheniramine maleate mixture, betamethasone valerate/gentamicin sulfate, methylprednisolone, and methylprednisolone sodium succinate

ISSN: 2055-0294